loperamide hydrochloride /lōper″əmīd/ , an antiperistaltic drug. ▪ INDICATIONS: It is prescribed in the treatment of diarrhea. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. It is not given to patients in whom constipation must be avoided. ▪ ADVERSE EFFECTS: Among the most serious effects are abdominal pain, constipation, nausea, and vomiting.