loads [AS, lad, support] , (Slang) a fixed combination of a sedative hypnotic (glutethimide) and a major opioid analgesic (codeine), which is taken orally by drug abusers for a euphoric effect reported to be similar to that produced by heroin but longer lasting. Toxicity may develop, characterized by nystagmus, slurred speech, seizures, coma, pulmonary edema, or sudden apnea and death. Detoxification of an addicted person is managed under close medical supervision with methadone and phenobarbital, as sudden withdrawal can cause death.