lipoatrophic diabetes /lip′ō·atrof″ik/ , an inherited disease characterized by a total loss of subcutaneous body fat, insulin-resistant diabetes mellitus, acanthosis nigricans, hypermetabolism, hepatomegaly, and hypertrophied musculature. It is associated with a disorder of the hypothalamus that results in excessive blood levels of growth hormone and adrenocorticotropic-releasing hormones. Also called congenital total lipodystrophy.
