lepirudin, a direct thrombin inhibitor. ▪ INDICATIONS: It is used to treat heparin-induced thrombocytopenia and other thromboembolic conditions. ▪ CONTRAINDICATIONS: Known hypersensitivity to hirudins prohibits its use. ▪ ADVERSE EFFECTS: Life-threatening effects of lepirudin include heart failure, pericardial effusion, ventricular fibrillation, multiorgan failure, sepsis, hematuria, hemorrhage, intracranial bleeding, and thrombocytopenia. Other adverse effects include GI bleeding, abnormal liver function tests, abnormal kidney function, pneumonia, and allergic skin reactions. Fever is a common side effect. Drug interactions with NSAIDs, aspirin, salicylates, and antiplatelets may occur. Use of the herbs feverfew, ginkgo, ginger, and valerian may potentiate bleeding. Caution should be used in its use in patients with cirrhosis of the liver.
