leiomyofibroma /lī′ōmī′ōfībrō″mə/ pl. leiomyofibromas, leiomyofibromata [Gk, leios, smooth, mys, muscle; L, fibra, fiber; Gk, oma, tumor] , a tumor consisting of smooth muscle cells and fibrous connective tissue, commonly occurring in the uterus in middle-aged women. See also fibroid.