lamotrigine /lämo′trijēn/ , an anticonvulsive used in treatment of certain forms of epilepsy. ▪ INDICATIONS: It is prescribed as adjunct therapy in the treatment of partial seizures in epilepsy patients over the age of 16 and as an adjunct therapy for children under 16 years of age with generalized seizures associated with Lennox-Gastaut syndrome. It is not approved for use in children less than 2 years of age. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: The most serious adverse effects include hepatotoxicity, potentially life-threatening rash, and Stevens-Johnson syndrome. When discontinued, the drug should be tapered off gradually over a 2-week period to avoid patient risk-rebound effect.
