ketoconazole /-kō″nəzōl/ , an antifungal agent. ▪ INDICATIONS: It is prescribed for the treatment of candidiasis, coccidioidomycosis, histoplasmosis, and other fungal diseases. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. It should not be used for fungal meningitis. Because it is also an inhibitor of some important drug metabolizing enzymes and can cause toxic intermediates from other drugs to accumulate, the safe use of ketoconazole with other prescribed medications should be verified. ▪ ADVERSE EFFECTS: The most serious adverse effects are liver disorders.
