isocarboxazid /-kärbok″səzid/ , a monoamine oxidase inhibitor. ▪ INDICATIONS: It is prescribed in the treatment of mental depression. ▪ CONTRAINDICATIONS: Liver or kidney dysfunction; congestive heart failure; pheochromocytoma; concomitant use of a sympathomimetic drug or foods high in tryptophan, tyramine, or caffeine; or known hypersensitivity to the drug prohibits its use. Must be used with caution in patients with suicidal ideation. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are hyperactivity, cardiac arrhythmia, hypotension, vertigo, dryness of mouth, constipation, and blurred vision. Monoamine oxidase inhibitors produce many adverse drug interactions.
