isoantigen /ī′sō·an″tijən/ [Gk, isos + anti, against; AS, boding, body; Gk, Geenen, to produce] , a substance present in some members of a species that stimulates production of antibodies in other members of the species. Also called alloantigen. Compare autoantigen, autoimmune disease. Kinds include blood group antigen. See also antigen.