infant botulism, an intoxication by neurotoxins produced by Clostridium botulinum that occurs in children less than 6 months of age. The condition is characterized by severe hypotonicity of all muscles, constipation, lethargy, and feeding difficulties, and it may lead to respiratory insufficiency. The botulism neurotoxin is usually found in the GI tract rather than in the blood, indicating that it is probably produced in the gut rather than ingested. The epidemiological and pathophysiological characteristics of the syndrome are not clearly understood. ▪ INTERVENTIONS: Treatment is supportive, including optimal management of fluids, electrolytes, and nutrition. Ventilatory support may also be necessary. There is no evidence that antitoxin therapy is helpful, and it is usually not recommended.
