immunomodulator /-mod″yəlā′tər/ [L, immunis + modulus, little measure] , a substance that alters the immune response by augmenting or reducing the ability of the immune system to respond to antigens. Immunomodulators include corticosteroids, cytotoxic agents, thymosin, and immunoglobulins. Some immunomodulators are naturally present in the body, and some of these are available in pharmacological preparations. −immunomodulation, n.