imipenem-cilastatin sodium /im′ipē″nəm sil′əstat″in/ , a broad-spectrum parenteral antibiotic. ▪ INDICATIONS: It is prescribed for the treatment of infections caused by susceptible organisms in the lower respiratory or urinary tracts, skin, abdomen, reproductive organs, bones, or joints. It is also used in the treatment of endocarditis and septicemia. ▪ CONTRAINDICATIONS: It is not recommended for children. Caution should be used in administering it to patients with pseudomembranous colitis, hypersensitivity reactions, or a history of seizures. ▪ ADVERSE EFFECTS: The most common adverse effects are phlebitis, thrombophlebitis, nausea, vomiting, diarrhea, rash, fever, and central nervous system symptoms.
