idursulfase, a rarely used enzyme replacement. ▪ INDICATIONS: This drug is used to treat mucopolysaccharidosis II. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug or other systemic antifungal or azoles, fungal meningitis, and onchomycosis or dermatomycosis in cardiac function prohibit its use. ▪ ADVERSE EFFECTS: Adverse effects of this drug include insomnia, fever, rigors, weakness, anxiety, hypertension, hypotension, tachycardia, anemia, cramps, abdominal pain, flatulence, gynecomastia, impotence, decreased libido, malaise, hypokalemia, and tinnitus. Life-threatening side effects include GI bleeding, hepatotoxicity, toxic epidermal necrolysis, and rhabdomyolysis. Common side effects include headache, dizziness, nausea, vomiting, anorexia, diarrhea, pruritus, rash, edema, and fatigue.
