ibuprofen /ī″byo̅o̅″prōfin/ , a COX-1 over-the-counter nonsteroidal antiinflammatory agent. ▪ INDICATIONS: It is used for the treatment of fever, headaches, and pain from rheumatoid arthritis and osteoarthritis, muscle aches, and menstrual cramps. ▪ CONTRAINDICATIONS: Renal dysfunction, disorders of the GI tract, or known hypersensitivity to this drug, to other nonsteroidal antiinflammatory drugs, or to aspirin prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are GI disturbances, gastric or duodenal ulceration, dizziness, skin rash, and tinnitus.
