hypogammaglobulinemia /-gam′əglō′byəlinē″mē·ə/ [Gk, hypo + gamma, third letter in Greek alphabet; L, globus, small sphere; Gk, haima, blood] , lower than normal concentration of plasma gamma globulin, usually the result of increased protein catabolism or loss of protein via the urine. It is associated with a decreased resistance to infection. Also spelled hypogammaglobulinaemia. Compare agammaglobulinemia.