hyoscyamine /hī′əsī″əmēn/ , an anticholinergic/antispasmodic drug. ▪ INDICATIONS: It is prescribed in the treatment of hypermotility of the GI and lower urinary tracts and is used preoperatively to reduce secretions and block vagal inhibitory effects on the heart. ▪ CONTRAINDICATIONS: Narrow-angle glaucoma, asthma, obstruction of the genitourinary or GI tract, severe ulcerative colitis, or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are blurred vision, central nervous system effects, tachycardia, dry mouth, decreased sweating, and hypersensitivity reactions.