hyaluronidase /hī′əlyo͝oron″ədās/ , an enzyme that hydrolyzes hyaluronic acid, a component of the extracellular matrix. ▪ INDICATIONS: It is prescribed to increase the absorption and dispersion of parenteral drugs that have extravasated (e.g., vesicant chemotherapeutics), for hypodermoclysis, and for improvement of resorption of radiopaque agents. ▪ CONTRAINDICATIONS: Acute inflammation, infection, or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: The most serious adverse effect is hypersensitivity.
