hemoglobin SC (Hb SC) disease, a genetic anemia in which abnormal alleles, one for hemoglobin S and one for hemoglobin C, are inherited. The disorder is characterized by a clinical course considerably less severe than that of sickle cell anemia despite the absence of normal hemoglobin. Also called sickle cell–hemoglobin C disease. See also hemoglobin C disease, sickle cell anemia.