Hay-Wells syndrome /hā welz/ [R.J. Hay, British dermatologist, 20th century; Robert Stuart Wells, British dermatologist, 20th century] , an autosomal-dominant syndrome of ectodermal dysplasia, cleft lip and palate, and ankyloblepharon. It is also characterized by hypodontia, palmar and plantar keratoderma, partial anhidrosis, sparse wiry hair, and sometimes otological defects. Also called AEC syndrome, ankyloblepharon–ectodermal dysplasia–clefting syndrome.