frontal lobe, the largest of five lobes constituting each of the two cerebral hemispheres. It lies beneath the frontal bone; occupies part of the lateral, medial, and inferior surfaces of each hemisphere; and extends posteriorly to the central sulcus and inferiorly to the lateral fissure. It is responsible for voluntary control over most skeletal muscles. The frontal lobe significantly influences personality and is associated with the higher mental activities, such as planning, judgment, emotion, and conceptualization. Compare central lobe, occipital lobe, parietal lobe, temporal lobe.