fluorouracil /flo͝or′ōyo͝or″əsil/ , an antimetabolite antineoplastic drug. ▪ INDICATIONS: It is prescribed in the treatment of malignant neoplastic disease of the skin, breast, and internal organs. ▪ CONTRAINDICATIONS: Bone marrow depression, infection, poor nutritional status, or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are severe depression of the bone marrow and acute GI disturbances, including nausea, vomiting, diarrhea, and stomatitis. Alopecia and dermatitis commonly occur. Effects of topical application include photosensitivity, rash, and scarring.
