Fanconi’s syndrome [Guido Fanconi] , a group of disorders that includes pancytopenia, renal tubular dysfunction, glycosuria, phosphaturia, and bicarbonate wasting. The condition is often marked by osteomalacia, acidosis, rickets, and hypokalemia. Two main types of the syndrome have been differentiated. Idiopathic Fanconi’s syndrome is an inherited autosomal-recessive disorder and usually accompanies other genetic disorders such as Wilson’s disease, galactosemia, or glycogen storage disease. Acquired Fanconi’s syndrome is usually the result of toxicity from various sources, including ingestion of outdated tetracycline, heavy metal poisoning, or vitamin D deficiency. Because of numerous variations of the syndrome, different alleles are believed responsible for the different recessively inherited factors expressed as signs and symptoms of the group of disorders.
