ethynodiol diacetate and ethinyl estradiol, an oral estrogen-progestin combination contraceptive. ▪ INDICATIONS: It is prescribed for prevention of pregnancy. ▪ CONTRAINDICATIONS: Thrombophlebitis, cardiovascular disease, breast or reproductive organ cancer, or known hypersensitivity to either ingredient prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse effects are thrombophlebitis, uterine fibroma, gallbladder disease, embolism, and hepatic lesions.