Eisenmenger’s syndrome /i′sən·meng′ərz/ [Victor Eisenmenger, German physician, 1864–1932] , ventricular septal defect with pulmonary hypertension and cyanosis resulting from right-to-left (reversed) shunt of blood. It is sometimes defined as pulmonary hypertension and cyanosis with the shunt being at the atrial, ventricular, or great vessel area.