dimethyl sulfoxide (DMSO) /dīmeth″il/ , an organic solvent used as an antiinflammatory agent. ▪ INDICATIONS: It is instilled into the bladder for the treatment of interstitial cystitis. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the most serious adverse reactions are GI disturbances, photophobia, disturbance of color vision, and headache. A garliclike body odor and taste in the mouth may occur. When applied topically, it can cause local irritations and carry toxins into the systemic circulation.