diflunisal /dīflo̅o̅″nisal/ , a nonsteroidal antiinflammatory drug. ▪ INDICATIONS: It is prescribed for the treatment of mild to moderate pain and inflammation in osteoarthritis and other musculoskeletal disorders. ▪ CONTRAINDICATIONS: Hypersensitivity to aspirin and other nonsteroidal antiinflammatory drugs or known sensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: The most serious adverse reactions are GI pain, diarrhea, peptic ulcer, anorexia, anaphylactoid reactions with bronchospasm, and edema.
