denileukin diftitox, a miscellaneous antineoplastic agent. ▪ INDICATIONS: It is used to treat cutaneous T cell lymphoma that expresses the CD25 component of the IL-2 receptor. ▪ CONTRAINDICATIONS: Hypersensitivity to denileukin, diphtheria toxin, or interleukin-2 prohibits its use. ▪ ADVERSE EFFECTS: Life-threatening effects are thrombocytopenia and leukopenia. Other serious side effects include hematuria, albuminuria, pyuria, creatinine increase, anemia, hypoalbuminemia, edema, hypocalcemia, dehydration, hypokalemia, infection, chest pain, and flu-like symptoms. Common side effects include dizziness, paresthesia, nervousness, confusion, insomnia, hypotension, vasodilation, tachycardia, thrombosis, hypertension, dysrhythmias, nausea, anorexia, vomiting, diarrhea, constipation, dyspepsia, and dysphagia.
