decongestant [L, de + congerere, to pile up] , 1. adj., pertaining to a substance or procedure that eliminates or reduces congestion or swelling. 2. n., a decongestant drug. Adrenergic drugs (α-1 stimulants), such as ephedrine and pseudoephedrine, that cause vasoconstriction of nasal mucosa are used as decongestants.