Crouzon’s disease /kro̅o̅zonz″/ [Octave Crouzon, French neurologist, 1874–1938; L, dis + Fr, aise, ease] , a genetic disorder caused by mutations in the FGFR2 gene, characterized by a malformed skull; various ocular disorders, including exophthalmos, strabismus, and optic atrophy; a beaked nose; and an underdeveloped upper jaw. In addition, individuals with Crouzon syndrome may have dental problems and hearing loss. Cleft lip and palate are sometimes present.
