Cronkhite-Canada syndrome /krong″kīt/ [Leonard W. Cronkhite, American physician, b. 1919; Wilma J. Canada, 20th-century American radiologist] , an abnormal familial condition characterized by GI polyposis accompanied by ectodermal defects, such as nail atrophy, alopecia, and excessive skin pigmentation. In some individuals it is also accompanied by protein-losing enteropathy, malabsorption, and deficiency of blood calcium, potassium, and magnesium.