comedocarcinoma /kom′idōkär′sinō″mə/ pl. comedocarcinomas, comedocarcinomata [L, comedere, to consume; Gk, karkinos, crab, oma, tumor] , a malignant intraductal neoplasm of the breast, in which the central cells degenerate and may be easily expressed from the cut surface of the tumor. Growth confined to the mammary ducts carries a better prognosis than do invasive breast lesions.