collagenase /kəlaj″ənās/ , a medication applied as an ointment for debridement of decubitus ulcers, burns, and other epidermal lesions. It is also injected into the penis for treatment of Peyronie’s disease and into the wrist, ankle, etc. for the treatment of Dupuytren’s disease (restricted movement caused by thickening of the fascia). It is an enzyme preparation derived from the fermentation of Clostridium histolyticum.
