colitis /kōlī″tis/ , an inflammatory condition of the large intestine. Inflammatory bowel disease is characterized by severe diarrhea, bleeding, and ulceration of the mucosa of the intestine. Weight loss and pain are significant. Steroids, fluids, electrolytes, antibiotics, and careful attention to diet are the usual modes of therapy. Most of the diseases of this group are of unknown origin. Kinds include Crohn’s disease, ulcerative colitis. −colitic, adj.