colistimethate sodium /kō′listim″əthāt/ , an antibiotic. Also called colistin sulfomethate sodium. ▪ INDICATIONS: It is prescribed in the treatment of GI infections caused by certain gram-negative microorganisms and as a topical medication. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse reactions are nephrotoxicity and neurotoxicity.