cimetidine /simet″idēn/ , an H2-receptor antagonist. ▪ INDICATIONS: It is prescribed to inhibit the production and secretion of acid in the stomach in the treatment of gastroesophageal reflux disease, pancreatitis, duodenal ulcers, and hypersecretory conditions. It is also used in the treatment of warts. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug prohibits its use. Not recommended with the use of tricyclic depressants. ▪ ADVERSE EFFECTS: Among the more serious adverse reactions are diarrhea, dizziness, rash, confusion (usually in elderly patients given large doses), and gynecomastia. Cimetidine inhibits several forms of cytochrome P450 and, therefore, has effects on many other drugs.
