chorioadenoma destruens /-des″tro̅o̅·əns/ [Gk, chorion + aden + oma + L, destruere, to pull down] , an invasive hydatidiform mole in which the chorionic villi of the mole penetrate into the myometrium and parametrium of the uterus and metastasize to distant parts of the body, most commonly to the lungs. Also called metastasizing mole.