chlorthalidone /-thal″idōn/ , a diuretic and antihypertensive; a sulfonamide derivative. ▪ INDICATIONS: It is prescribed in the treatment of high blood pressure and edema. ▪ CONTRAINDICATIONS: Anuria or known hypersensitivity to this drug, to other thiazide medication, or to sulfonamide derivatives prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse reactions are hypokalemia, hyperglycemia, hyperuricemia, and hypersensitivity reactions.