chlorambucil /klôr′ambo̅o̅″sil/ , an alkylating agent. ▪ INDICATIONS: It is prescribed in the treatment of a variety of malignant neoplastic diseases, including chronic lymphocytic leukemia and Hodgkin’s disease. ▪ CONTRAINDICATIONS: Bone marrow depression or known hypersensitivity to this drug prohibits its use. It is not given during pregnancy or within 28 days of chemotherapy or radiation therapy. Pregnancy should be avoided for 1 month after discontinuing use. ▪ ADVERSE EFFECTS: Among the more serious adverse reactions are bone marrow depression, GI disturbance, skin rash, and hepatotoxicity.
