Charcot-Marie-Tooth disease /shärkō″mərē″to̅o̅th″/ [Jean M. Charcot; Pierre Marie, French neurologist, 1853–1940; Howard H. Tooth, English neurologist, 1856–1925] , a progressive hereditary disorder characterized by degeneration of the peroneal muscles of the fibula, resulting in clubfoot, foot drop, and ataxia. Progressive arm weakness can also be present as distal muscles atrophy. Compare peripheral neuropathy.
