ceftriaxone sodium /sef′trī·ak″sōn/ , a parenteral third-generation cephalosporin antibiotic. ▪ INDICATIONS: It is prescribed for infections of the lower respiratory tract, urinary tract, skin, abdomen, bones, and joints. It is also used to treat gonorrhea, septicemia, and meningitis and in surgical prophylaxis, particularly in coronary bypass operations. It has a comparatively long half-life and although its dosage must still be decreased with renal impairment, it is one of the few cephalosporins that is eliminated primarily by the liver. ▪ CONTRAINDICATIONS: It is contraindicated in patients who are hypersensitive to this product or to other cephalosporin antibiotics. ▪ ADVERSE EFFECTS: Among reported adverse reactions are skin rash, diarrhea, eosinophilia, thrombocytosis, leukopenia, increased liver enzyme and blood urea nitrogen levels, and pain and tenderness at the site of injection.
