busulfan /bo̅o̅sul″fən/ , an alkylating agent. ▪ INDICATIONS: It is prescribed in the treatment of chronic myelocytic leukemia. ▪ CONTRAINDICATIONS: Radiation therapy, depressed neutrophil or platelet counts, concurrent administration of neoplastic medication, or known hypersensitivity to this drug prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse reactions are alveolar hyperplasia (busulfan lung), depression of the bone marrow, and severe nausea and diarrhea. Amenorrhea commonly occurs.
