aplasia cutis congenita [Gk, a, plassein; L, cutis, skin, congenitus, born with] , the congenital absence of a localized area of skin. The defect occurs predominantly on the scalp, less frequently on the limbs and trunk. It is usually covered by a thin, translucent membrane or scar tissue, or it may be raw and ulcerated. The condition is genetically transmitted, although the mode of inheritance is not known.