anti-DNA antibody test, a blood test that is useful for the diagnosis and follow-up of systemic lupus erythematosus (SLE). The test uses double-stranded deoxyribonucleic acid (DNA) as antigen to detect anti-DNA antibodies. High titers characterize SLE, and low to moderate levels may indicate other rheumatic diseases as well as chronic hepatitis, infectious mononucleosis, and biliary cirrhosis.
