alteplase, a tissue plasminogen activator. ▪ INDICATIONS: This drug is used for lysis of obstructing thrombi associated with acute MI and for other ischemic conditions requiring thrombolysis. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug, active internal bleeding, recent cerebrovascular accident, severe uncontrolled hypertension, intracranial trauma or surgery, intraspinal trauma or surgery, aneurysm, and brain tumor prohibit the use of this drug. ▪ ADVERSE EFFECTS: Adverse effects of this drug include urticaria and rash. Surface bleeding is a common side effect. Life-threatening side effects include sinus bradycardia, ventricular tachycardia, accelerated idioventricular rhythm, bradycardia, GI bleeding, genitourinary bleeding, intracranial bleeding, retroperitoneal bleeding, and anaphylaxis.
