adiposogenital dystrophy /ad′ipō′sōjen″itəl/ [L, adeps + genitalis, generation] , a disorder occurring in males, characterized by genital hypoplasia and feminine secondary sex characteristics, including female distribution of fat. It is caused by hypothalamic malfunction or by a tumor in the adenohypophysis. Hypothermia, hypotension, and hypoglycemia are frequently associated with the disorder. Diabetes insipidus also results from hyposecretion of antidiuretic hormone, which causes increased output of diluted urine, electrolyte imbalances, and thirst. In addition, involvement of the satiety center may induce overeating and result in pronounced obesity. If a tumor is present, there may be drowsiness and symptoms of increased intracranial pressure (for example, subtle locus of control changes and headache). Treatment may include the administration of testosterone and a weight-reduction program, excision or radiological ablation of a tumor, and replacement of hormones, as necessary. Also called Fröhlich’s syndrome.
