acute confusional state (ACS), a form of delirium caused by interference with the metabolic or other biochemical processes essential for normal brain functioning. Symptoms may include disturbances in cognition and levels of awareness, short-term memory deficit, retrograde and anterograde amnesia, and disturbances in orientation, accompanied by restlessness, apprehension, irritability, and apathy. The condition may be associated with an acute physiological state, delirium, toxic psychosis, or acute brain syndrome which constitutes a medical emergency.