acromegalic eunuchoidism /-məgal″ik/ , a rare disorder characterized by genital atrophy and development of female secondary sex characteristics occurring in men with advanced acromegaly caused by a tumor in the anterior pituitary gland. Initially the gonadal function of the anterior lobe may be stimulated, but with the growth of the tumor the patient may become impotent; lose facial, axillary, and pubic hair; and acquire soft skin and a feminine distribution of fat. Also called retrograde infantilism.