cortisol /kôr″təsôl/ , a steroid hormone produced naturally by the adrenal gland, identical to chemically synthesized hydrocortisone. ▪ INDICATIONS: It is prescribed for adrenocortical insufficiency, topically for inflammation, and as an adjunct for the treatment of ulcerative colitis. ▪ CONTRAINDICATIONS: Fungal infections or known hypersensitivity to this drug prohibits its systemic use. Viral or fungal infections of the skin, impaired circulation, or known hypersensitivity to this drug prohibits its topical use. ▪ ADVERSE EFFECTS: Among the more serious adverse reactions to this drug are GI, endocrine, neurological, fluid, and electrolyte disturbances. Hypersensitivity reactions may result from topical administration.