coagulation factor VIIa, recombinant

coagulation factor VIIa, recombinant, an antihemophilic. ▪ INDICATIONS: This drug is prescribed to prevent the bleeding associated with hemophilia A or B when inhibitors to Factor VIII or IX are present. ▪ CONTRAINDICATIONS: Factors that prohibit its use include known hypersensitivity to this product or to mouse-, hamster-, or bovine-derived products. ▪ ADVERSE EFFECTS: Life-threatening side effects include hemorrhage, hemarthrosis, decreased fibrinogen plasma, diffuse intravascular coagulation, coagulation disorder, and thrombosis. Other adverse effects include fever, headache, hypertension, bradycardia, pain, redness at the injection site, pruritus, purpura, and rash.