cloxacillin sodium /klok′səsil″in/ , a penicillinase-resistant penicillin used for bacterial infections. ▪ INDICATIONS: It is prescribed in the treatment of serious bacterial infections, primarily those caused by penicillinase-producing strains of staphylococci. ▪ CONTRAINDICATIONS: Known hypersensitivity to this drug or to any penicillin prohibits its use. ▪ ADVERSE EFFECTS: Among the more serious adverse reactions are GI discomfort, rash, and hypersensitivity.